Here's a look at some players that should take priority if you're hoping to pick up some reinforcements from the waiver wire.
Kenneth Walker, RB, Seahawks: The rookie had his best game Sunday, highlighted by a 67-yard touchdown. You'd expect him to lead the backfield now that Rashad Penny is out for the year with a broken fibula. He might not be as widely available on the waiver wire, but he's still not on rosters in some leagues.
Josh Reynolds, WR, Lions: The amount of leagues he's still available in is next to criminal. He caught six passes for 92 yards in Week 5. The good news is his production hasn't waivered no matter if the team is in the game or getting blown out like Sunday.
Jakobi Meyers, WR, Patriots: Upon returning from injury, Meyers made his presence felt right away as he caught seven passes for 111 yards and a touchdown in the beatdown of the Lions on Sunday. He's in good position to continue to be productive even with a rookie QB at the helm.
Rondale Moore, WR, Cardinals: You can feel fine dropping Greg Dortch and replacing him with Moore, which is what Arizona may do. Moore caught seven passes for 68 yards and got two opportunities to run the ball as well. He has a shot to blow up and is worthy of a roster spot.
Khalil Shakir, WR, Bills: The rookie had his first quality game with Jamison Crowder and Isaiah McKenzie out for the prolific Buffalo offense. Shakir could still be useful in coming weeks with Crowder expected to miss more time and McKenzie dealing with concussion protocol.
Eno Benjamin, RB, Cardinals: Both James Conner and Darrel Williams got injured Sunday and Benjamin ended up scoring. He stands to get a lot more work if both running backs are out or limited in Week 6 against the Seahawks, who have a tough time against the position.
Marquez Valdes-Scantling, WR, Chiefs: He had a season high 90 yards receiving in the win over the Raiders on Monday night. With the wideout position a bit of a grab bag for the Chiefs, it's possible the former Packer can be useful in fantasy.
Geno Smith, QB, Seahawks: It's time to give in, as Gatosclub.com contributor Sam Bissett said last week, Smith should be taken seriously as a streaming QB. He's now had three consecutive good performances and outside games with the Giants and Bucs, the next five games should be plus-matchups for him. Smith could be useful in Week 7 if you normally start Josh Allen, Jalen Hurts, Matthew Stafford or Kirk Cousins.
Alec Pierce, WR, Colts: I suggested him last week and he's still widely available after catching eight passes for 81 yards in the win over the Broncos. He's become pretty reliable for Matt Ryan, who's struggled to gain chemistry with the other receivers.
Deon Jackson, RB, Colts: The Colts took another seemingly improbable win Thursday night, beating the Broncos on the road without Jonathan Taylor. Nyheim Hines was supposed to be the replacement for Taylor, but he suffered a concussion early in the game, giving Jackson the opportunity. Taylor could return in Week 6, so adding Jackson is a risk.
Tevin Coleman, RB, 49ers: He scored twice in Week 5 after having a slow start to the season. With the injuries to the backfield, he got a chance Sunday to show he can still be useful as a 29-year-old. Jeff Wilson could end up giving away some touches to the veteran.
Dyami Brown, WR, Commanders: It could just be a blip on the season, but his performance Sunday makes you take notice. He caught just two passes, but both went for scores and amassed 105 yards.